.docx, .pptx, .xlsx are file extentions used by Microsoft 2007 and later. They signify the new file type used by that program.
If you are using Office 2007 or later it is very helpful if you change the default save format to .doc, .xls, or .ppt based on the particular program. This is easy to do in the options section of Word, PowerPoint, and Excel. Once you change the default setting then anyone can open the files you create.
If you run across a .docx, .pptx, or .xlsx file and can't open it the odds are you're using Office 2003 (or 2004 on the Mac) and you don't have the Microsoft file converter installed. You can get that free from the Microsoft site at:
http://www.microsoft.com/downloads/details.aspx?FamilyId=941B3470-3AE9-4AEE-8F43-C6BB74CD1466&displaylang=enOnce you download and install that you will be able to open .docx files and similar with your Office 2003 program.